Can you take gemfibrozil and simvastatin together?

Using gemfibrozil together with simvastatin is not recommended. Combining these medications can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue.

What is the relationship between statin and gemfibrozil?

Gemfibrozil, one of the fibrates, but not fenofibrate, interferes with statin glucuronidation, which may increase the risk of myopathy due to elevations in statin serum levels.

What’s the difference between gemfibrozil and simvastatin?

Both drugs were generally well tolerated. In conclusion, simvastatin was more effective in reducing total cholesterol and LDL-C levels, whereas gemfibrozil was more effective in reducing VLDL-C and triglyceride levels. There was no deterioration of glycemic control in patients treated with simvastatin.

Is there an interaction between simvastatin and amlodipine?

Concurrent use of amlodipine and simvastatin causes a significant increase in blood levels of simvastatin such that, in practice, the effect is double that compared to uninhibited simvastatin. Therefore, in patients on amlodipine 10mg plus simvastatin 20mg, the effect is similar to receiving simvastatin 40mg alone.

What are the contraindications of gemfibrozil?

Who should not take GEMFIBROZIL?

anemia.
decreased blood platelets.
low levels of white blood cells.
liver problems.
gallstones.
disease of the gallbladder.
a mother who is producing milk and breastfeeding.
a progressive liver disease called primary biliary cholangitis.

What is the side effects of gemfibrozil?

The more common side effects that can occur with use of gemfibrozil include:

stomach upset.
stomach pain.
nausea.
vomiting.
diarrhea.
constipation.
rash.
dizziness.

What drugs does simvastatin interact with?

Some products that may interact with this drug include: “blood thinners” (such as warfarin), cyclosporine, danazol, daptomycin, gemfibrozil. Other medications can affect the removal of simvastatin from your body, which may affect how simvastatin works.

What medicines should not be taken with amlodipine?

Some medicines can interfere with the way amlodipine works. Tell your doctor if you’re taking any of these medicines before starting amlodipine: the antibiotics clarithromycin, erythromycin or rifampicin. medicines for high blood pressure, including diltiazem and verapamil.

Is gemfibrozil hard on the kidneys?

Gemfibrozil (Lopid) can cause muscle damage, which can lead to kidney damage or even kidney failure. The risk is higher if you’re also taking a statin medication. Talk to your provider if you develop sudden muscle pain, weakness, or dark-colored urine.

Are there any drug interactions with simvastatin oral?

All generic drug interactions for simvastatin oral (lists will include brand and generic names): gemfibrozil oral and simvastatin oral. gemfibrozil oral will increase the level or effect of simvastatin oral by Other mechanism. Combination increases risk of muscle damage.

Is the drug simvastatin the same as gemfibrozil?

The study uses data from the FDA. It is based on gemfibrozil and simvastatin (the active ingredients of Gemfibrozil and Simvastatin, respectively), and Gemfibrozil and Simvastatin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

How is gemfibrozil related to cyclosporine and statin interactions?

Gemfibrozil and its glucuronide inhibit CYP2C8 and OATP1B1. These effects of cyclosporine and gemfibrozil explain the increased plasma statin concentrations and, together with pharmacodynamic factors, the increased risk of myotoxicity when coadministered with statins.

How is simvastatin acid metabolized in the body?

Simvastatin, lovastatin, and atorvastatin are metabolized by cytochrome P450 (CYP) 3A4 (simvastatin acid is also metabolized by CYP2C8); their plasma concentrations and risk of myotoxicity are greatly increased by strong inhibitors of CYP3A4 (eg, itraconazole and ritonavir).

Can you take gemfibrozil and simvastatin together? Using gemfibrozil together with simvastatin is not recommended. Combining these medications can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. What is the relationship between statin and gemfibrozil? Gemfibrozil, one…