What drugs should not be taken with phenytoin?

Drugs that increase phenytoin blood levels and toxicity include:

acute alcohol intake,
amiodarone (Coradone),
chlordiazepoxide,
cimetidine (Tagamet),
diazepam (Valium, Diastat),
dicumarol,
disulfiram,
estrogens,

What is contraindicated with phenytoin?

Hypersensitivity to phenytoin or other hydantoins is a contraindication for using phenytoin. Pregnancy is another absolute contraindication for phenytoin use.

What precautions would you take for a patient on phenytoin?

This medicine may cause drowsiness, trouble thinking, or trouble in controlling movements. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Avoid drinking alcohol while you are using this medicine.

What is the interaction between valproic acid and phenytoin?

These results suggest that valproic acid may have two separate and opposing effects on phenytoin disposition: (1) displacing phenytoin from plasma protein binding sites, thereby enhancing the systemic clearance of total drug, and (2) inhibiting phenytoin metabolism, thereby increasing the concentration of free drug in …

Is phenytoin a high risk medication?

The high-alert medications were: amiodarone, digoxin, dopamine, epinephrine, fentanyl, gentamycin, heparine, insulin, morphine, norepinephrine, phenytoin, potassium, propofol and tacrolimus.

What are the symptoms of Dilantin toxicity?

Symptoms

Coma.
Confusion.
Staggering gait or walk (early sign)
Unsteadiness, uncoordinated movements (early sign)
Involuntary, jerky, repeated movement of the eyeballs called nystagmus (early sign)
Seizures.
Tremor (uncontrollable, repeated shaking of the arms or legs)
Sleepiness.

What is the purpose of phenytoin?

Phenytoin is a medicine used to treat epilepsy. It can also be used to treat trigeminal neuralgia, a type of nerve pain that affects your face. Phenytoin is available on prescription.

What drugs should not be taken with phenytoin? Drugs that increase phenytoin blood levels and toxicity include: acute alcohol intake, amiodarone (Coradone), chlordiazepoxide, cimetidine (Tagamet), diazepam (Valium, Diastat), dicumarol, disulfiram, estrogens, What is contraindicated with phenytoin? Hypersensitivity to phenytoin or other hydantoins is a contraindication for using phenytoin. Pregnancy is another absolute contraindication for phenytoin…